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Responses of sodium balance, blood pressure, and other variables to sodium loading in Papua New Guinea highlanders.

Authors
  • Rikimaru, T
  • Fujita, Y
  • Okuda, T
  • Kajiwara, N
  • Miyatani, S
  • Alpers, M P
  • Koishi, H
Type
Published Article
Journal
The American journal of clinical nutrition
Publication Date
Mar 01, 1988
Volume
47
Issue
3
Pages
502–508
Identifiers
PMID: 3348162
Source
Medline
License
Unknown

Abstract

For determination of the responses of sodium balance, blood pressure, and other relevant variables to Na loading in people with a low intake of Na, 10 male Papua New Guinea highland subjects were given additional Na at two levels (128 and 256 mmol/d) for 10 d after a 3-d control period of low-Na diet. Na loading caused a marked positive balance of Na, decreases of aldosterone concentration and renin activity in the plasma, and a decrease of urinary aldosterone excretion. The blood pressure, particularly that measured at noon, increased in the latter half of the Na-loading period, the increase being significant in the group given 256 mmol of sodium daily: the systolic and diastolic blood pressure increased from 92 +/- 8 over 56 +/- 7 mm Hg in the control period to 102 +/- 7 over 60 +/- 4 mm Hg in the latter half of the test period (p less than 0.05).

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