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Responses of human skin in organ culture and human skin fibroblasts to a gadolinium-based MRI contrast agent: comparison of skin from patients with end-stage renal disease and skin from healthy subjects.

Authors
  • DaSilva, Marissa
  • O'Brien Deming, Monica
  • Fligiel, Suzanne E G
  • Dame, Michael K
  • Johnson, Kent J
  • Swartz, Richard D
  • Varani, James
Type
Published Article
Journal
Investigative Radiology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Nov 01, 2010
Volume
45
Issue
11
Pages
733–739
Identifiers
DOI: 10.1097/RLI.0b013e3181e9436b
PMID: 20661146
Source
Medline
License
Unknown

Abstract

These data indicate that Omniscan exposure alters an enzyme/inhibitor system responsible for regulating collagen turnover in the skin and directly stimulates hyaluronan production. The higher basal levels of type I procollagen, matrix metalloproteinase-1, tissue inhibitor of metalloproteinases-1, and hyaluronan in the skin from ESRD patients could contribute to the sensitivity of this patient population to fibrotic changes, which might be induced by exposure to some of the gadolinium-based contrast agents.

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