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Response to “Variable directionality of gene expression changes across generations does not constitute negative evidence of epigenetic inheritance” Sharma, A. Environmental Epigenetics, 2015, 1-5

Authors
  • Szabó, Piroska E.1
  • 1 Van Andel Research Institute, Center for Epigenetics, 333 Bostwick Ave, Grand Rapids, MI, 49503, USA , Grand Rapids (United States)
Type
Published Article
Publication Date
May 16, 2016
Volume
17
Issue
1
Identifiers
DOI: 10.1186/s13059-016-0978-0
Source
Springer Nature
Keywords
License
Green

Abstract

Abhay Sharma brings two arguments in favor of transgenerational epigenetic inheritance (TGEI) in mammals when criticizing our work. He uses probability calculations and finds that the probability of obtaining the number of common changes in the in utero-exposed prospermatogonia and the same cells in the next generation is significant in our study. He also compares our results to other published datasets and concludes that the probability for the observed overlap between independent studies is significant. We disagree with both arguments of Sharma and show here that his meta-analysis and statistical calculations are not correct.

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