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Response to TNF-α Is Increasing Along with the Progression in Barrett's Esophagus.

Authors
  • Chemnitzer, Olga1
  • Götzel, Katharina1
  • Maurer, Luisa1
  • Dietrich, Arne1, 2
  • Eichfeld, Uwe1
  • Lyros, Orestis1
  • Jansen-Winkeln, Boris1
  • Hoffmeister, Albrecht3
  • Gockel, Ines1
  • Thieme, René4
  • 1 Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Medical Center Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany. , (Germany)
  • 2 Integrated Research and Treatment Center (IFB) Adiposity Diseases, University Medical Center Leipzig, Philipp-Rosenthal-Strasse 27, 04103, Leipzig, Germany. , (Germany)
  • 3 Department of Gastroenterology and Rheumatology, University Medical Center Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany. , (Germany)
  • 4 Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Medical Center Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany. [email protected] , (Germany)
Type
Published Article
Journal
Digestive Diseases and Sciences
Publisher
Springer-Verlag
Publication Date
Dec 01, 2017
Volume
62
Issue
12
Pages
3391–3401
Identifiers
DOI: 10.1007/s10620-017-4821-6
PMID: 29086334
Source
Medline
Keywords
License
Unknown

Abstract

The increased basal expression levels of IL-8 with the progression of Barrett's esophagus constrain NFκB activation and its contribution in the manifestation of Barrett's esophagus. An anti-inflammatory compound, such as curcumin, could create an anti-inflammatory microenvironment and thus potentially support an increase chemosensitivity in EAC cells.

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