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Response and Side Effects Using Stimulant Medication in Older Adults With ADHD: An Observational Archive Study.

Authors
  • Michielsen, Marieke1
  • Kleef, Didi1
  • Bijlenga, Denise1
  • Zwennes, Cinderella1
  • Dijkhuizen, Kim1
  • Smulders, Jan1
  • Hazewinkel, Andreia1
  • Beekman, Aartjan T F2
  • Kooij, J J Sandra1
  • 1 PsyQ, Expertise Center Adult ADHD, The Hague, The Netherlands. , (Netherlands)
  • 2 VU University Medical Center, Amsterdam, The Netherlands. , (Netherlands)
Type
Published Article
Journal
Journal of Attention Disorders
Publisher
SAGE Publications
Publication Date
Oct 01, 2021
Volume
25
Issue
12
Pages
1712–1719
Identifiers
DOI: 10.1177/1087054720925884
PMID: 32508213
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Objective: To examine the naturalistic response to and cardiovascular side effects of stimulant medication in older adults with ADHD. Methods: Electronic Health Record (EHR) data of adult patients with ADHD (≥55 years) at the specialized PsyQ outpatient clinic for adult ADHD (n = 113, 55-79 years) were collected. Response, cardiovascular status, side effects, and provided medical care before and after the first ADHD medication dose have been recorded. Results: A total of 65% of the patients reported positive response to the medication, and 42% of the patients quit their medication due to side effects or nonresponse. There was a small but significant decrease in weight and increase in heart rate before and after methylphenidate use. Conclusion: Our results indicate that the use of stimulants may be a relatively safe and effective treatment for older adults with ADHD, under the condition that the cardiovascular parameters are monitored before and during pharmacological treatment. Randomized controlled trials (RCTs) are needed to confirm these findings.

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