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The response of oscillating glycolysis to perturbations in the NADH/NAD system: a comparison between experiments and a computer model.

Authors
  • Richter, O
  • Betz, A
  • Giersch, C
Type
Published Article
Journal
Biosystems
Publisher
Elsevier
Publication Date
Jul 01, 1975
Volume
7
Issue
1
Pages
137–146
Identifiers
PMID: 168933
Source
Medline
Language
English
License
Unknown

Abstract

The glycolytic pathway is described by a set of coupled non linear differential equations of first order with respect to time. The individual terms of these equations consist of enzyme velocities assuming a steady state hypothesis for the enzymatic forms. These are specified and the system is solved numerically. Oscillations are explained by interaction of PFK with the adenylate system. The conditions for the occurrence of oscillations are tested in a series of computer runs. The phase relations between intermediates of the model agree with those found in yeast cells. As an application of the model the disturbation of oscillations by the addition of acetaldehyde is simulated. The predictions of the model agree with experimental results.

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