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Response of Dental Pulp Stem Cells to Synthetic, Allograft, and Xenograft Bone Scaffolds.

Authors
  • Motamedian, Saeed Reza
  • Tabatabaei, Fahime Sadat
  • Akhlaghi, Fahimeh
  • Torshabi, Maryam
  • Gholamin, Parisan
  • Khojasteh, Arash
Type
Published Article
Journal
The International journal of periodontics & restorative dentistry
Publication Date
Jan 01, 2017
Volume
37
Issue
1
Pages
49–59
Identifiers
DOI: 10.11607/prd.2121
PMID: 27977818
Source
Medline
License
Unknown

Abstract

Different degrees of clinical success have been reported for synthetic, allograft, and xenograft bone substitutes in human trials. Although these substitutes have been clinically investigated, their in vitro effects on cell differentiation remain unclear. Proliferation, differentiation, and attachment of dental pulp stem cells (DPSCs) to β-tricalcium phosphate (β-TCP), freeze-dried bone allograft (FDBA), and deproteinized bovine bone mineral (DBBM) were compared in this study. MTT assay, measurement of total DNA, and reverse transcriptase polymerase chain reaction were performed. β-TCP had the highest potential for DPSC attachment and proliferation, while FDBA induced osteoblastic differentiation of DPSCs. Further in vivo investigations are necessary to select a clinically appropriate scaffold.

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