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Response to comments on: Entecavir resistance mutations rtL180M/T184L/M204V combined with rtA200V lead to tenofovir resistance.

Authors
  • Jiang, Dong1, 2
  • Zeng, Hui1, 2
  • Wang, Xianbo3
  • 1 Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. , (China)
  • 2 Beijing Key Laboratory of Emerging infectious Diseases, Beijing, China. , (China)
  • 3 Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China. , (China)
Type
Published Article
Journal
Liver international : official journal of the International Association for the Study of the Liver
Publication Date
Dec 07, 2019
Identifiers
DOI: 10.1111/liv.14319
PMID: 31811784
Source
Medline
Language
English
License
Unknown

Abstract

We thank Zheng et al for their interest in our recent study (1, 2). First, our and others' study did not identify identical TDF-resistant mutants. Firstly, more mutations were need to hurdle higher genetic barrier. HBV is easy to develop resistant mutation for LAM with low genetic barrier, all LAM resistant mutants contain mutation of rtM204. Whereas for high genetic barrier inhibitor ETV, resistance was mostly developed in three site combination mutations. © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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