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Respiratory management of motor neurone disease: a review of current practice and new developments.

Authors
  • Rafiq, Muhammad Khizar
  • Proctor, Alison Ruth
  • McDermott, Christopher J
  • Shaw, Pamela J
Type
Published Article
Journal
Practical neurology
Publication Date
Jun 01, 2012
Volume
12
Issue
3
Pages
166–176
Identifiers
DOI: 10.1136/practneurol-2011-000199
PMID: 22661348
Source
Medline
License
Unknown

Abstract

Motor neurone disease is a neurodegenerative condition with a significant morbidity and shortened life expectancy. Hypoventilatory respiratory failure is the most common cause of death and respiratory function significantly predicts both survival and quality of life in patients with motor neurone disease. Accordingly, supporting and maintaining respiratory function is important in caring for these patients. The most significant advance in motor neurone disease care of recent years has been the domiciliary provision of non-invasive ventilation for treating respiratory failure. Neuromuscular respiratory weakness also leads to ineffective cough and retained airways secretions, predisposing to recurrent chest infections. In this review, we discuss current practice and recent developments in the respiratory management of motor neurone disease, in terms of ventilatory support and cough augmentation.

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