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Resolving Binding Events on the Multifunctional Human Serum Albumin

Authors
  • Wenskowsky, Lea1
  • Wagner, Michael2
  • Reusch, Johannes3
  • Schreuder, Herman2
  • Matter, Hans2
  • Opatz, Till1
  • Petry, Stefan Matthias2
  • 1 Johannes Gutenberg-University, Germany , (Germany)
  • 2 Industriepark Höchst, Germany , (Germany)
  • 3 Lochhamer Straße 15, Germany , (Germany)
Type
Published Article
Journal
ChemMedChem
Publisher
Wiley (John Wiley & Sons)
Publication Date
Mar 19, 2020
Volume
15
Issue
9
Pages
738–743
Identifiers
DOI: 10.1002/cmdc.202000069
PMID: 32162429
PMCID: PMC7318646
Source
PubMed Central
Keywords
License
Unknown
External links

Abstract

Your true colors : A trichromatic fluorescent binding and displacement assay for simultaneous monitoring and localization of three individual binding sites on HSA was developed using highly specific binding molecules. Whereas localization is confirmed by X‐ray analysis, kinetic data are independently confirmed by switchSENSE technology, revealing important data on conformational changes.

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