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Resolution of positional isomers by capillary electrochromatography.

Authors
  • Hindocha, D
  • Smith, N W
Type
Published Article
Journal
Journal of Chromatography A
Publisher
Elsevier
Publication Date
Dec 22, 2000
Volume
904
Issue
1
Pages
99–106
Identifiers
PMID: 11209905
Source
Medline
License
Unknown

Abstract

Electroseparations have been very successful in increasing efficiencies and reducing analysis times. The analytical technique originally applied to open tube capillaries (capillary electrophoresis) has been used as a basis to develop renewed interest in electrochromatography. This paper describes the use of capillary electrochromatography to separate two positional isomers and describes a comparison between gas chromatography (GC), capillary electrochromatography (CEC) and nano-HPLC. The resolution of these isomers is quite crucial, since one of the isomers is the impurity in a pharmaceutically active drug.

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