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Resistoflavine, cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN1/7.

Authors
  • Gorajana, Adinarayana
  • Venkatesan, M
  • Vinjamuri, Saisha
  • Kurada, Bapiraju V V S N
  • Peela, Sujatha
  • Jangam, Premkumar
  • Poluri, Ellaiah
  • Zeeck, Axel
Type
Published Article
Journal
Microbiological Research
Publisher
Elsevier
Publication Date
Jan 01, 2007
Volume
162
Issue
4
Pages
322–327
Identifiers
PMID: 16580188
Source
Medline
License
Unknown

Abstract

In our systematic screening programme for marine actinomycetes, a bioactive Streptomycete was isolated from marine sediment samples of Bay of Bengal, India. The taxonomic studies indicated that the isolate belongs to Streptomyces chibaensis and it was designated as S. chibaensis AUBN1/7. The isolate yielded a cytotoxic compound. It was obtained by solvent extraction followed by the chromatographic purification. Based on the spectral data of the pure compound, it was identified as quinone-related antibiotic, resistoflavine (1). It showed a potent cytotoxic activity against cell lines viz. HMO2 (Gastric adenocarcinoma) and HePG2 (Hepatic carcinoma) in vitro and also exhibited weak antibacterial activities against Gram-positive and Gram-negative bacteria.

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