The antibiotic resistancy of Bordetella pertussis to erythromicin, chloramphenicol and tetracyclin has been examined using Disc diffusion method described by Kirby bauer (1966) on Charcoal agar contains 10% sheep blood. The examination was done on positive culture which had been collected from 233 nasopharyngeal swab specimens. The results showed that no resistant to erythromicin (0%). Mean while there was significant resistancy to chloramphenicol (5,6%) and tetracyclin (25%). Antibiotic treatment should be given rationally to gain efficiency in antibiotic usage, to avoid antibiotic resistancy and to minimize cost of treatment.