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Resistance of strongylid nematodes to anthelmintic drugs and driving factors at Czech goat farms

Authors
  • Vadlejch, Jaroslav1
  • Kyriánová, Iveta Angela1
  • Várady, Marián2
  • Charlier, Johannes3
  • 1 Czech University of Life Sciences Prague, Kamýcká 129, Prague, Suchdol, 165 00, Czech Republic , Prague (Czechia)
  • 2 Slovak Academy of Sciences, Košice, 040 01, Slovak Republic , Košice (Slovakia)
  • 3 Kreavet, Hendrik Mertensstraat 17, Kruibeke, 9150, Belgium , Kruibeke (Belgium)
Type
Published Article
Journal
BMC Veterinary Research
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Mar 05, 2021
Volume
17
Issue
1
Identifiers
DOI: 10.1186/s12917-021-02819-8
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundStrongylid nematode infections may negatively affect both animal health and welfare, with deleterious consequences for livestock productivity. Many farmers in recent decades have relied on anthelmintics as the sole strategy of control, but the intensive use of these chemotherapeutics has led to the development of anthelmintic resistance (AR). Knowledge of both the efficacy of anthelmintics and factors promoting AR are essential to effectively control nematode infections, but no information on these topics for goats in the Czech Republic (CR) is available. This survey aimed to determine the occurrence of AR at Czech goat farms and to identify risk factors for the development of AR. A total of 24 herds of dairy goats across the CR were evaluated using in vitro tests for detecting AR, and a questionnaire survey was carried out to evaluate factors associated with AR.ResultsResistance against benzimidazoles was confirmed at 18 (75%) farms, and the level of resistance was high in four (22%) of the affected herds based on the egg hatch test. Ivermectin-resistant nematodes were detected in 13 (54%) herds using the larval development test; Teladorsagia/Trichostrongylus and Haemonchus were the predominant types of resistant larvae. Eight (62%) of the affected herds were evaluated as highly resistant to ivermectin. Eleven (46%) of the herds were resistant to both benzimidazoles and ivermectin. This report is the first on dual AR in the CR. A univariate logistic regression analysis indicated that a high stocking rate and farmer inexperience were significantly associated with ivermectin and benzimidazole resistance, respectively.ConclusionsThe results of our survey suggest that AR is widespread amongst herds of dairy goats in the CR, likely due to inappropriate practices of pasture and health management. AR may be an issue for expanding dairy-goat production in the CR in the near future unless both veterinary practitioners and farmers widely adopt strategies to prevent the development of AR.

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