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Research and therapy with induced pluripotent stem cells (iPSCs): social, legal, and ethical considerations

Authors
  • Moradi, Sharif1, 2
  • Mahdizadeh, Hamid1
  • Šarić, Tomo3
  • Kim, Johnny4
  • Harati, Javad5
  • Shahsavarani, Hosein5, 6
  • Greber, Boris7
  • Moore, Joseph B. IV8, 8
  • 1 Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran , Tehran (Iran)
  • 2 Royan Institute for Stem Cell Biology and Technology, ACECR, Isar 11, 47138-18983, Babol, Iran , Babol (Iran)
  • 3 University of Cologne, Cologne, 50931, Germany , Cologne (Germany)
  • 4 Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany , Bad Nauheim (Germany)
  • 5 Pasteur Institute of Iran, Tehran, Iran , Tehran (Iran)
  • 6 Shahid Beheshti University, Tehran, Iran , Tehran (Iran)
  • 7 RheinCell Therapeutics GmbH, Langenfeld, 40764, Germany , Langenfeld (Germany)
  • 8 University of Louisville, Louisville, KY, USA , Louisville (United States)
Type
Published Article
Journal
Stem Cell Research & Therapy
Publisher
Springer Nature America, Inc
Publication Date
Nov 21, 2019
Volume
10
Issue
1
Identifiers
DOI: 10.1186/s13287-019-1455-y
Source
Springer Nature
Keywords
License
Green

Abstract

Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate into all specialized cell types including gametes. iPSCs do not exist naturally and are instead generated (“induced” or “reprogrammed”) in culture from somatic cells through ectopic co-expression of defined pluripotency factors. Since they can be generated from any healthy person or patient, iPSCs are considered as a valuable resource for regenerative medicine to replace diseased or damaged tissues. In addition, reprogramming technology has provided a powerful tool to study mechanisms of cell fate decisions and to model human diseases, thereby substantially potentiating the possibility to (i) discover new drugs in screening formats and (ii) treat life-threatening diseases through cell therapy-based strategies. However, various legal and ethical barriers arise when aiming to exploit the full potential of iPSCs to minimize abuse or unauthorized utilization. In this review, we discuss bioethical, legal, and societal concerns associated with research and therapy using iPSCs. Furthermore, we present key questions and suggestions for stem cell scientists, legal authorities, and social activists investigating and working in this field.

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