Blue Origin's New Shepard launch vehicle made its first flight above the Kármán Line, returning safely to Earth in November 2015. At the time when this paper is being written (February 2021), the system has conducted 14 flights, including 10 with research and education payloads aboard. More than 100 payloads have exercised a wide range of capabilities and interfaces, from small cubesat-form factor student payloads to large custom payloads of nearly 100 kg. Investigations have spanned a wide range of high-altitude and microgravity research objectives, as well as raising technology readiness level (TRL) on diverse hardware. This paper summarizes New Shepard's payload missions to date, and presents standardized and custom accommodations, both in the shirtsleeve cabin and directly exposed to the space environment.