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Rescue of axotomized retinal ganglion cells by BDNF gene electroporation in adult rats.

Authors
  • Mo, Xiaofen
  • Yokoyama, Akiko
  • Oshitari, Toshiyuki
  • Negishi, Hisanari
  • Dezawa, Mari
  • Mizota, Atsushi
  • Adachi-Usami, Emiko
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Jul 01, 2002
Volume
43
Issue
7
Pages
2401–2405
Identifiers
PMID: 12091443
Source
Medline
License
Unknown

Abstract

These findings demonstrate that electroporation is an effective method for the direct delivery of genes into RGCs, and that the BDNF gene transferred into RGCs by in vivo electroporation can protect axotomized RGCs against apoptosis.

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