Affordable Access

The requirement of thymus competence for both humoral and cell-mediated steps in expulsion of Nippostorngylus brasiliensis from mice.

Authors
  • Jacobson, R H
  • Reed, N D
Type
Published Article
Journal
International archives of allergy and applied immunology
Publication Date
Jan 01, 1976
Volume
52
Issue
1-4
Pages
160–168
Identifiers
PMID: 1017887
Source
Medline
License
Unknown

Abstract

The worm damaging process (step 1 of Nippostrongylus brasiliensis expulsion from rodents) does not occur in congenitally thymus-deficient (nude) mice as determined by worm morphology, female worm fecundity, and kinetics of worm expulsion upon transfer into normal rats. Expulsion of damaged N. brasiliensis (step 2) does not occur subsequent to transfer of such worms from rats into nude mice. Morphological changes and reduced fecundity appeared in adult worms from normal thymus-bearing mice as early as the first day of patency (day 6 of infection). Thus, the worm damaging process is initiated several days earlier in mice than in rats and may, therefore, account for the reduced longevity of N. brasiliensis in mice compared with rats.

Report this publication

Statistics

Seen <100 times