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Requirement offlex (femalelethal onX) in the development of the female germ line ofDrosophila melanogaster

Authors
  • Bhattacharya, Ananya1
  • Sudha, S.1
  • Balakrishna, Swathi1
  • Chandra, H. Sharat1, 2
  • 1 Indian Institute of Science, Department of Microbiology and Cell Biology, Bangalore, 560012, India , Bangalore
  • 2 Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, 560 064, India , Bangalore
Type
Published Article
Journal
Journal of Genetics
Publisher
Springer-Verlag
Publication Date
Dec 01, 1999
Volume
78
Issue
3
Pages
133–139
Identifiers
DOI: 10.1007/BF02934458
Source
Springer Nature
Keywords
License
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Abstract

Drosophila melanogaster females homozygous forflex, an X-linked recessive mutation, do not survive. Hemizygous males are unaffected. Homozygous embryos appear to lack SXL, the product of theSex-lethal (Sxl) gene, apparently as a result of disruption ofSxl splicing. It is known that bothSxl and its somatic splicing regulators [snf andfl(2)d] also function in the development of the female germ line. For this reason, we investigated the role offlex in the germ line by generatingflex/flex clones inflex/+ females. Females carrying such clones in their germ lines do not lay eggs whereas females carryingflex+ eggs lay viable eggs. Additionally, DAPI staining of ovarioles showed that diploid germ cells that are homozygous mutant forflex do not complete oogenesis. These results indicate that theflex+ gene product may be required for the development of the female germ line.

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