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The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron

Authors
  • Bucher, John R.
  • Tien, Ming
  • Aust, Steven D.
Type
Published Article
Journal
Biochemical and Biophysical Research Communications
Publication Date
Jan 01, 1983
Volume
111
Issue
3
Pages
777–784
Identifiers
DOI: 10.1016/0006-291X(83)91366-9
Source
Elsevier
Keywords
License
Unknown

Abstract

When certain ferrous chelates are added to lipid, peroxidation of the lipid occurs following a short lag. This suggests that a product of ferrous autoxidation is required to initiate lipid peroxidation. This autoxidation product is apparently ferric iron, rather than the oxygen radicals which also result from ferrous autoxidation. Studies with oxy-radical scavengers and catalase suggest that O 2 • H 2O 2, or the ·OH are not involved in the initiation reactions, therefore, we propose that a ferrous-dioxygen-ferric chelate complex may be the initiating species.

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