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Reptiles in Guadeloupe (French West Indies) are a reservoir of major human Salmonella enterica serovars.

Authors
  • Guyomard-Rabenirina, Stéphanie1
  • Weill, François-Xavier2
  • Le Hello, Simon2
  • Bastian, Sylvaine3
  • Berger, Franck4, 5
  • Ferdinand, Séverine1
  • Legreneur, Pierre6
  • Loraux, Cécile3
  • Malpote, Edith3
  • Muanza, Blandine7
  • Richard, Vincent8
  • Talarmin, Antoine1
  • Breurec, Sébastien1, 3, 9
  • 1 Unité Transmission, Réservoir et Diversité des Pathogènes, Institut Pasteur de Guadeloupe, Les Abymes, France. , (France)
  • 2 Unité des Bactéries pathogènes entériques, Centre National de Référence des Escherichia coli, Shigella et Salmonella, Institut Pasteur, Paris, France. , (France)
  • 3 Laboratoire de Microbiologie clinique et environnementale, Centre Hospitalier Universitaire de Pointe-à-Pitre/les Abymes, Pointe-à-Pitre, France. , (France)
  • 4 Service de Santé des Armées, Centre d'épidémiologie et de santé publique des armées, Marseille, France. , (France)
  • 5 INSERM, IRD, Sciences Economiques et Sociales de la Santé et Traitement de l'Information Médicale, Université d'Aix Marseille, Marseille, France. , (France)
  • 6 CRIS EA 647, Université de Lyon, Villeurbanne, France. , (France)
  • 7 Service de Pédiatrie, Centre Hospitalier Universitaire de Pointe-à-Pitre/les Abymes, Pointe-à-Pitre, France. , (France)
  • 8 Institut Pasteur de Nouvelle-Calédonie, Nouméa, Nouvelle-Calédonie.
  • 9 Faculté de Médecine Hyacinthe Bastaraud, Université des Antilles, Pointe-à-Pitre, France. , (France)
Type
Published Article
Journal
PLoS ONE
Publisher
Public Library of Science
Publication Date
Jan 01, 2019
Volume
14
Issue
7
Identifiers
DOI: 10.1371/journal.pone.0220145
PMID: 31323053
Source
Medline
Language
English
License
Unknown

Abstract

The epidemiology of human Salmonella enterica infections in Guadeloupe (French West Indies) appears to be specific, with a higher prevalence of the subspecies enterica serovars Panama and Arechavaleta (Panama and Arechavaleta) than in other regions. A study was performed in Guadeloupe to identify the reservoir of Salmonella serovars by comparing their distribution in warm- and cold-blooded animals and in humans living in Guadeloupe and mainland France. Furthermore, a case-control study was conducted in 2012-2013 to identify the main epidemiologic risk factors for S. enterica infection among children under 15 years of age. Between June 2011 and December 2014, feces from 426 reptiles (322 anoles, 69 iguanas and 35 geckos) and 50 frogs distributed throughout Guadeloupe and nearby islands were investigated. The frequency of S. enterica carriage was 15.0% (n = 64) in reptiles but varied by species. The only significant risk factor for S. enterica infection was a more frequent presence of frogs in the houses of cases than in those of controls (P = 0.042); however, isolates were not collected. Panama and Arechavaleta were the two serovars most often recovered between 2005 and 2014 from humans living in Guadeloupe (24.5% (n = 174) and 11.5% (n = 82), respectively), which is in contrast to the low prevalence in mainland France (0.4%). Their presence at low frequencies in wild reptiles (4.6% (n = 3) and 3.1% (n = 2), respectively) and pigs (7.5% (n = 5) and 1.5% (n = 1), respectively) suggests a broad host range, and humans may be infected by indirect or direct contact with animals. These serovars are probably poorly adapted to humans and therefore cause more severe infections. The unusual subspecies houtenae serovar 43:z4,z32:- was a major subspecies in wild reptiles (24.6%, n = 16) and humans (9.4%, n = 67) but was not recovered from warm-blooded animals, suggesting that reptiles plays a key role in human infection.

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