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Reproducibility and Changes in Vena Caval Blood Flow by Using 4D Flow MRI in Pulmonary Emphysema and Chronic Obstructive Pulmonary Disease (COPD): The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Substudy.

Authors
  • Rahman, Ozair1
  • Markl, Michael1
  • Balte, Pallavi1
  • Berhane, Haben1
  • Blanken, Carmen1
  • Suwa, Kenichiro1
  • Dashnaw, Stephen1
  • Wieben, Oliver1
  • Bluemke, David A1
  • Prince, Martin R1
  • Lima, Joao1
  • Michos, Erin1
  • Ambale-Venkatesh, Bharath1
  • Hoffman, Eric A1
  • Gomes, Antoinette S1
  • Watson, Karol1
  • Sun, Yanping1
  • Carr, James1
  • Barr, R Graham1
  • 1 From the Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611 (O.R., M.M., H.B., C.B., K.S., J.C.); Departments of Radiology (O.R., S.D., M.R.P., Y.S.), Medicine (P.B., Y.S., R.G.B.), and Epidemiology (R.G.B.), Columbia University Medical Center, New York, NY; Department of Radiology, NewYork-Presbyterian Hospital, New York, NY (O.R.); Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Ill (M.M.); Departments of Medical Physics (O.W.) and Radiology (D.A.B.), University of Wisconsin School of Medicine and Public Health, Madison, Wis; Division of Cardiology, Johns Hopkins University, Baltimore, Md (J.L., E.M., B.A.V.); Department of Radiology, Biomedical Engineering and Medicine, University of Iowa, Iowa City, Iowa (E.A.H.); and Departments of Radiology (A.S.G.) and Medicine (K.W.), University of California Los Angeles, Los Angeles, Calif.
Type
Published Article
Journal
Radiology
Publisher
Radiological Society of North America
Publication Date
Sep 01, 2019
Volume
292
Issue
3
Pages
585–594
Identifiers
DOI: 10.1148/radiol.2019182143
PMID: 31335282
Source
Medline
Language
English
License
Unknown

Abstract

BackgroundChronic obstructive pulmonary disease (COPD) is associated with hemodynamic changes in the pulmonary vasculature. However, cardiac effects are not fully understood and vary by phenotype of chronic lower respiratory disease.PurposeTo use four-dimensional (4D) flow MRI for comprehensive assessment of the right-sided cardiovascular system, assess its interrater and intraobserver reproducibility, and examine associations with venous return to the right heart in individuals with chronic COPD and emphysema.Materials and MethodsThe Multi-Ethnic Study of Atherosclerosis COPD substudy prospectively recruited participants who smoked and who had COPD and nested control participants from population-based samples. Electrocardiography and respiratory gated 4D flow 1.5-T MRI was performed at three sites with full volumetric coverage of the thoracic vessels in 2014-2017 with postbronchodilator spirometry and inspiratory chest CT to quantify percent emphysema. Net flow, peak velocity, retrograde flow, and retrograde fraction were measured on 14 analysis planes. Interrater reproducibility was assessed by two independent observers, and the principle of conservation of mass was employed to evaluate the internal consistency of flow measures. Partial correlation coefficients were adjusted for age, sex, race/ethnicity, height, weight, and smoking status.ResultsAmong 70 participants (29 participants with COPD [mean age, 73.5 years ± 8.1 {standard deviation}; 20 men] and 41 control participants [mean age, 71.0 years ± 6.1; 22 men]), the interrater reproducibility of the 4D flow MRI measures was good to excellent (intraclass correlation coefficient range, 0.73-0.98), as was the internal consistency. There were no statistically significant differences in venous flow parameters according to COPD severity (P > .05). Greater percent emphysema at CT was associated with greater regurgitant flow in the superior and inferior caval veins and tricuspid valve (adjusted r = 0.28-0.55; all P < .01), particularly in the superior vena cava.ConclusionFour-dimensional flow MRI had good-to-excellent observer variability and flow consistency. Percent emphysema at CT was associated with statistically significant differences in retrograde flow, greatest in the superior vena cava.© RSNA, 2019Online supplemental material is available for this article.See also the editorial by Choe in this issue.

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