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Repositioned Drugs for Inflammatory Diseases such as Sepsis, Asthma, and Atopic Dermatitis

Authors
  • Prakash, Annamneedi Venkata
  • Park, Jun Woo
  • Seong, Ju-Won
  • Kang, Tae Jin
Type
Published Article
Journal
Biomolecules & Therapeutics
Publisher
The Korean Society of Applied Pharmacology
Publication Date
Mar 05, 2020
Volume
28
Issue
3
Pages
222–229
Identifiers
DOI: 10.4062/biomolther.2020.001
PMID: 32133828
PMCID: PMC7216745
Source
PubMed Central
Keywords
License
Green

Abstract

The process of drug discovery and drug development consumes billions of dollars to bring a new drug to the market. Drug development is time consuming and sometimes, the failure rates are high. Thus, the pharmaceutical industry is looking for a better option for new drug discovery. Drug repositioning is a good alternative technology that has demonstrated many advantages over de novo drug development, the most important one being shorter drug development timelines. In the last two decades, drug repositioning has made tremendous impact on drug development technologies. In this review, we focus on the recent advances in drug repositioning technologies and discuss the repositioned drugs used for inflammatory diseases such as sepsis, asthma, and atopic dermatitis.

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