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Reporter mice and drug discovery and development.

Authors
  • 1
Type
Published Article
Journal
Nature reviews. Drug discovery
Publication Date
Volume
4
Issue
3
Pages
249–255
Identifiers
DOI: 10.1038/nrd1661
PMID: 15738979
Source
Medline

Abstract

In vivo reporter gene and imaging technologies have the potential to contribute to the drug discovery pipeline in several areas. They provide systems that enable the study of the biochemical activity of a target in disease, and in response to a drug, to be monitored over periods of time, and offer more accurate methods of measuring pharmacodynamics and toxicity. Although reporter-gene technology is in its infancy, with further refinement reporter animals could become a valuable tool in the early stages of target and lead identification and preclinical drug development.

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