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Replicon: a software to accurately predict DNA replication timing in metazoan cells.

Authors
  • Gindin, Yevgeniy
  • Meltzer, Paul S
  • Bilke, Sven
Type
Published Article
Journal
Frontiers in Genetics
Publisher
Frontiers Media SA
Publication Date
Jan 01, 2014
Volume
5
Pages
378–378
Identifiers
DOI: 10.3389/fgene.2014.00378
PMID: 25404939
Source
Medline
Keywords
License
Unknown

Abstract

Eukaryotic DNA replication follows a strict temporal program where genomic loci are replicated at precise times during the S phase of the cell cycle. Yet, the mechanism in control of the timing program in metazoan cells is poorly understood. In a recent publication, the authors proposed an intuitive stochastic model of DNA replication and showed that it predicts replication timing with an accuracy approaching the level of experimental biological repeats. Here, we discuss an extended software implementation of the mechanistic model: Replicon. This package allows interested researchers to predict the global replication timing program in human cells from chromatin data.

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