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Replication-Coupled Nucleosome Assembly in the Passage of Epigenetic Information and Cell Identity.

Authors
  • Serra-Cardona, Albert1
  • Zhang, Zhiguo2
  • 1 Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Department of Pediatrics, Columbia University, New York, NY 10032, USA; Department of Genetics and Development, Columbia University, New York, NY 10032, USA.
  • 2 Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA; Department of Pediatrics, Columbia University, New York, NY 10032, USA; Department of Genetics and Development, Columbia University, New York, NY 10032, USA. Electronic address: [email protected]
Type
Published Article
Journal
Trends in Biochemical Sciences
Publisher
Elsevier
Publication Date
Feb 01, 2018
Volume
43
Issue
2
Pages
136–148
Identifiers
DOI: 10.1016/j.tibs.2017.12.003
PMID: 29292063
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

During S phase, replicated DNA must be assembled into nucleosomes using both newly synthesized and parental histones in a process that is tightly coupled to DNA replication. This DNA replication-coupled process is regulated by multitude of histone chaperones as well as by histone-modifying enzymes. In recent years novel insights into nucleosome assembly of new H3-H4 tetramers have been gained through studies on the classical histone chaperone CAF-1 and the identification of novel factors involved in this process. Moreover, in vitro reconstitution of chromatin replication has shed light on nucleosome assembly of parental H3-H4, a process that remains elusive. Finally, recent studies have revealed that the replication-coupled nucleosome assembly is important for the determination and maintenance of cell fate in multicellular organisms. Copyright © 2017 Elsevier Ltd. All rights reserved.

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