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Replenishment of Hepatitis B Virus cccDNA Pool Is Restricted by Baseline Expression of Host Restriction Factors In Vitro

Authors
  • brezgin, sergey
  • kostyusheva, anastasiia
  • bayurova, ekaterina
  • gordeychuk, ilya
  • isaguliants, maria
  • goptar, irina
  • nikiforova, anastasiia
  • smirnov, valery
  • volchkova, elena
  • glebe, dieter
  • kostyushev, dmitry
  • chulanov, vladimir
Publication Date
Nov 06, 2019
Identifiers
DOI: 10.3390/microorganisms7110533
OAI: oai:mdpi.com:/2076-2607/7/11/533/
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

-H2AX foci and demonstrated that HBV inflicts and DNMT3A aggravates DNA damage, possibly by downregulating DNA damage response factors. Additionally, suppression of HBV replication by DNMT3A may be related to reduced ATM/ATR expression. Conclusion: Formation and maintenance of HBV cccDNA pools may be partially suppressed by the baseline expression of host inhibitory factors including APOBEC3A and APOBEC3B. HBV inflicts DNA damage both directly and by inducing DNMT3A expression.

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