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Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex and cortical excitability in patients with major depressive disorder.

Authors
  • Bajbouj, Malek
  • Brakemeier, Eva-Lotta
  • Schubert, Florian
  • Lang, Undine E
  • Neu, Peter
  • Schindowski, Christina
  • Danker-Hopfe, Heidi
Type
Published Article
Journal
Experimental neurology
Publication Date
Dec 01, 2005
Volume
196
Issue
2
Pages
332–338
Identifiers
PMID: 16194530
Source
Medline
License
Unknown

Abstract

Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex is a relatively non-invasive technique with putative therapeutic effects in major depression. However, the exact neurophysiological basis of these effects needs further clarification. Therefore, we studied the impact of ten daily sessions of left, dorsolateral prefrontal rTMS on motor cortical excitability, as revealed by transcranial magnetic stimulation-elicited motor-evoked potentials in 30 patients. As compared to the non-responders, responders (33%) showed changes in parameters pointing towards a reduced cortical excitability. These results suggest that repetitive transcranial magnetic stimulation of the dorsolateral, prefrontal cortex may have inhibitory effects on motor cortical neuronal excitability in patients with major depressive disorder. Furthermore, measurement of motor cortical excitability may be a useful tool for investigating and monitoring inhibitory brain effects of antidepressant stimulation techniques like rTMS.

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