Affordable Access

Access to the full text

Repeated lumbar punctures within 3 days may affect CSF biomarker levels

Authors
  • Olsson, Martin1, 2, 3, 4
  • Ärlig, Johan1, 2, 3
  • Hedner, Jan3, 5
  • Blennow, Kaj1, 2
  • Zetterberg, Henrik1, 2, 5, 6, 7
  • 1 Sahlgrenska University Hospital, House V, Mölndal, 431 80, Sweden , Mölndal (Sweden)
  • 2 University of Gothenburg, Mölndal, Sweden , Mölndal (Sweden)
  • 3 University of Gothenburg, Gothenburg, Sweden , Gothenburg (Sweden)
  • 4 Sahlgrenska University Hospital/Östra, Gothenburg, Sweden , Gothenburg (Sweden)
  • 5 Sahlgrenska University Hospital, Gothenburg, Sweden , Gothenburg (Sweden)
  • 6 UCL Institute of Neurology, Queen Square, London, UK , London (United Kingdom)
  • 7 UK Dementia Research Institute at UCL, London, UK , London (United Kingdom)
Type
Published Article
Journal
Fluids and Barriers of the CNS
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Dec 13, 2019
Volume
16
Issue
1
Identifiers
DOI: 10.1186/s12987-019-0157-2
Source
Springer Nature
Keywords
License
Green

Abstract

Lumbar puncture (LP) is a common way of collecting cerebrospinal fluid (CSF) both in the clinic and in research. In this extension of a study on the relationship between sleep deprivation and CSF biomarkers for Alzheimer’s disease, we investigated CSF biomarker dynamics in relation to rebound sleep after sleep deprivation. Two LPs were performed within 3 days in 13 healthy volunteers. We noticed an unexpected sharp rise in biomarker concentrations in the second sample and therefore repeated the experiment, but without sleep intervention, in four additional individuals. The findings were similar in these subjects, suggesting an inherent methodological problem with repeated LPs. The result corroborates findings in studies with repeated CSF collection via indwelling lumbar catheters, and needs to be addressed in, for instance, pharmacodynamic studies employing these techniques.

Report this publication

Statistics

Seen <100 times