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Repeatability of ocular surface vessel density measurements with optical coherence tomography angiography

  • Cai, Sijie1
  • Zhao, Fengping2, 3
  • Du, Chixin1
  • 1 First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, Hangzhou, China , Zhejiang (China)
  • 2 Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu, Zhejiang, 322000, China , Yiwu (China)
  • 3 Yiwu Traditional Chinese Medicine Hospital, Jinhua, 322000, China , Jinhua (China)
Published Article
BMC Ophthalmology
Springer (Biomed Central Ltd.)
Publication Date
Dec 10, 2019
DOI: 10.1186/s12886-019-1255-2
Springer Nature


BackgroundTo determine the repeatability of measurements of ocular surface vessel density in normal and diseased eyes using optical coherence tomography angiography (OCTA).MethodsTen normal eyes, 10 pinguecula eyes, and 10 pterygium eyes of 30 volunteers were subjected to OCTA (AngioVue Imaging System, Optovue, Inc.). For scanning, we used the corneal adapter module. Each eye was scanned three times in the nasal and temporal directions, separately. AngioVue software was used to generate the ocular surface vessel density. Ocular surface vessel density was defined as the proportion of vessel area with blood flow to the total measurement area (3 × 3 mm2). Intersession repeatability of the measurement was summarized as the coefficient of variation (CV), and intraclass correlation coefficients (ICC) were calculated by variance component models.ResultsThe CVs were less than 5% in all subjects, and the ICCs exceeded 0.9; thus, all measurements showed good repeatability. The nasal vessels densities differed significantly between healthy eyes and eyes with pterygium (P < 0.05); however, there was no significant difference between healthy eyes and eyes with pinguecula (P = 0.466).ConclusionsThese results suggest that measurement of ocular surface vessel density by OCTA in normal eyes and eyes with pterygium and pinguecula is repeatable. This preliminary research describes a quantitative and visual method for assessing vessel density of the ocular surface with a high level of consistency.

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