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Is the Renin-Angiotensin-Aldosterone System Good for the Kidney in Acute Settings?

Authors
  • Dudoignon, Emmanuel
  • Dépret, François
  • Legrand, Matthieu
Type
Published Article
Journal
Nephron
Publisher
S. Karger AG
Publication Date
Apr 18, 2019
Volume
143
Issue
3
Pages
179–183
Identifiers
DOI: 10.1159/000499940
PMID: 30999307
Source
Karger
Keywords
License
Green
External links

Abstract

The renin-angiotensin-aldosterone system (RAAS) plays a major role in the regulation of blood pressure, renal hemodynamic, myocardial contractility via an enzymatic cascade leading to the synthesis of angiotensin 2. The activation of the RAAS system after acute kidney injury triggers renal inflammation and fibrotic process with long-term damaging consequences. To date, there is still a debate on the benefits of RAAS for the kidney in acute settings. Effects of RAAS antagonists are variable in chronic or acute conditions. The aim of this review is to discuss the renal and systemic effects of the RAAS, and its modulation, in acute situations.

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