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Renal urate transport.

Authors
  • Mount, David B
  • Kwon, Charles Y
  • Zandi-Nejad, Kambiz
Type
Published Article
Journal
Rheumatic diseases clinics of North America
Publication Date
May 01, 2006
Volume
32
Issue
2
Identifiers
PMID: 16716882
Source
Medline
License
Unknown

Abstract

Serum uric acid is determined by a balance between production and renal excretion. Luminal reabsorption of urate by the proximal tubule from the glomerular ultrafiltrate involves coupling between sodium-anion cotransport and urate-anion exchange. Apical sodium-coupled cotransport of lactate, ketoacids, nicotinate, and pyrazinoate increases intracellular levels of these anions in proximal tubular cells, stimulating the apical absorption of luminal urate via anion exchange. Hyperuricemia occurs when plasma levels of these anions increase; for example, hyperuricemia is a well-recognized concomitant of lactic acidosis and ketoacidosis. Relevant developments in the molecular and renal physiology of urate homeostasis are reviewed.

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