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Renal outcome in equipotent antihypertensive treatment with telmisartan, ramipril and in combination in SHR-SP rats.

Authors
  • Schmerbach, K
  • Kalk, P
  • Wengenmayer, C
  • Lucht, K
  • Unger, T
  • Hocher, B
  • Thoene-Reineke, C
Type
Published Article
Journal
Clinical laboratory
Publication Date
Jan 01, 2012
Volume
58
Issue
7-8
Pages
625–633
Identifiers
PMID: 22997963
Source
Medline
License
Unknown

Abstract

ACEI/ARB combination treatment failed to render significant additional benefits on renal outcome in hypertensive rats when compared to monotherapy. Instead our data indicate that dual RAAS blockade might have an adverse effect on kidney function and histology when compared to monotherapy in salt-loaded SHR-SP.

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