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Renal intravascular large B cell lymphoma: the first case report in Korea and a review of the literature

Authors
  • Kim, Moonsik
  • Chung, Haerim
  • Yang, Woo Ick
  • Jeong, Hyeon Joo
Type
Published Article
Journal
Journal of Pathology and Translational Medicine
Publisher
The Korean Society of Pathologists and the Korean Society for Cytopathology
Publication Date
Aug 13, 2020
Volume
54
Issue
5
Pages
426–431
Identifiers
DOI: 10.4132/jptm.2020.06.18
PMID: 32781826
PMCID: PMC7483029
Source
PubMed Central
Keywords
License
Unknown

Abstract

Herein, we describe the first case of renal intravascular large B cell lymphoma in Korea occurring in a 66-year-old female. She presented with mild fever and dyspnea. On physical and laboratory evaluations, hemophagocytic lymphohistiocytosis was suspected, but the bone marrow biopsy results were unremarkable. During the work-up, massive proteinuria developed, which led to a renal biopsy. The renal architecture was relatively well-preserved, but the glomeruli were hypercellular with the infiltration of atypical, large lymphoid cells with increased nucleus-cytoplasm ratio and clumped chromatin. Similar cells were also present in the peritubular capillaries. The tumor cells exhibited membranous staining for CD20 and CD79a. After the diagnosis of intravascular large B cell lymphoma, the patient received rituximab-based chemotherapy under close follow-up.

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