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Renal handling of urate in the syndrome of inappropriate secretion of antidiuretic hormone.

Authors
Type
Published Article
Journal
Archives of Internal Medicine
0003-9926
Publisher
American Medical Association
Publication Date
Volume
145
Issue
11
Pages
2045–2047
Identifiers
PMID: 4062456
Source
Medline

Abstract

Three patients with the syndrome of inappropriate secretion of antidiuretic hormone had elevated uric acid clearances. Their uric acid clearances decreased markedly after the administration of pyrazinamide. Probenecid was given to two of them and it produced large increases in uric acid clearance. These data suggest that enhanced secretion in the renal tubules was responsible for the increased clearance of uric acid. This article provides evidence that hypouricemia in the syndrome of inappropriate secretion of antidiuretic hormone is due to increased tubular urate secretion.

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