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Renal effects of dichloroacetate in vivo.

Authors
  • Kodama, H
  • Yamaguchi, S
  • Okabe, I
  • Kodama, M
  • Orii, T
  • Kamoshita, S
Type
Published Article
Journal
Clinica Chimica Acta
Publisher
Elsevier
Publication Date
Nov 15, 1986
Volume
160
Issue
3
Pages
265–271
Identifiers
PMID: 3791636
Source
Medline
License
Unknown

Abstract

We have investigated the effect of dichloroacetate (DCA) on the urinary excretion of lactate and pyruvate in a patient with congenital lactic acidosis and in healthy human controls. DCA administered orally in doses of 50 mg/kg and 30 mg/kg decreased plasma lactate and pyruvate of both the patient and the controls, while the urinary excretion of lactate and pyruvate was increased. However, these urinary increments were too small to contribute to the decrease of plasma lactate and pyruvate.

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