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Renal cell carcinoma with unusual metachronous metastasis up to 22 years after nephrectomy: two case reports

Authors
  • Bruckschen, F.1
  • Gerharz, C. D.2
  • Sagir, A.1
  • 1 Department of Gastroenterology, Academic Teaching Hospital Bethesda Duisburg, Heerstr. 219, 47053 Duisburg, Germany
  • 2 Department of Pathology, Academic teaching Hospital Bethesda Duisburg, Heerstr. 219, 47053 Duisburg, Germany
Type
Published Article
Journal
Journal of Medical Case Reports
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Oct 05, 2021
Volume
15
Identifiers
DOI: 10.1186/s13256-021-03098-5
PMID: 34607612
PMCID: PMC8491385
Source
PubMed Central
Keywords
Disciplines
  • Case Report
License
Unknown

Abstract

Introduction Renal cell carcinoma is the third most common malignant tumor in the urogenital tract. An estimated 25% of renal cell carcinomas are in stage IV when diagnosed. The 5-year-survival with stage IV is about 20%. Late metastases are found after an extended disease-free interval up to 20 years after primary nephrectomy. Case presentation Here, we present two cases with late-onset metastasis of renal cell carcinoma with different clinical presentations. The first patient, an 88-year-old Caucasian man, presented with bleeding of the upper gastrointestinal tract. Biopsies taken from the duodenal bulb showed a tumor compatible with a solitary metastasis from renal cell carcinoma 22 years ago. The second patient, a 79-year-old Caucasian man, consulted our gastroenterological department with results of an outpatient computed tomography scan with multiple suspected tumor areas in the liver, omentum, thyroid, and mediastinum. A computed tomography-guided liver biopsy was performed that showed a clear-cell tumor consistent with a metastasis of the renal cell carcinoma 17 years ago. Conclusion Both cases show that patients with a history of renal cell carcinoma should be followed up for a longer time than patients with other malignant tumors.

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