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Removal of potassium negative resistance in perfused squid giant axons.

Authors
  • Lecar, H
  • Ehrenstein, G
  • Binstock, L
  • Taylor, R E
Type
Published Article
Journal
The Journal of general physiology
Publication Date
Jul 01, 1967
Volume
50
Issue
6
Pages
1499–1515
Identifiers
PMID: 6034755
Source
Medline
License
Unknown

Abstract

Squid giant axons, internally and externally perfused with solutions having potassium as the only cation, exhibit an approximately linear steady-state current-voltage relation. When small amounts of calcium and magnesium are present in the external potassium solution, the current-voltage curve is markedly nonlinear, exhibiting the rectification and negative resistance which have been observed for intact axons in isosmotic potassium solutions. The effects of perfusion and removal of external divalent cations are interpreted in terms of two components of current, a linear component and a nonlinear time-varying component. The former is increased and the latter diminished by the removal of the external divalent cations.

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