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Removal of N-terminal methionine from haemoglobin nascent peptides by a membrane-bound rat liver methionine aminopeptidase.

Authors
Type
Published Article
Journal
The Biochemical journal
Publication Date
Volume
234
Issue
2
Pages
469–473
Identifiers
PMID: 3087345
Source
Medline
License
Unknown

Abstract

A membrane-bound aminopeptidase able to remove methionine from haemoglobin nascent peptides is described. The enzyme also hydrolyses methionine from methionyl-lysyl-bradykinin but not lysine from lysyl-bradykinin. The tripeptide Met-Ala-Ser is poorly hydrolysed. This aminopeptidase also splits amino acid 2-naphthylamides, being, however, less specific with respect to these synthetic substrates.

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