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Is Remote Ischemic Conditioning of Benefit to Patients Undergoing Kidney Transplantation?

Authors
  • Cheungpasitporn, Wisit1
  • Khoury, Nadeen J2
  • Thongprayoon, Charat3
  • Craici, Iasmina M1
  • 1 a Division of Nephrology, Department of Medicine , University of Mississippi Medical Center, Mississippi , Jackson , Mississippi USA.
  • 2 b Henry Ford Hospital Division of Nephrology and Hypertension, Department of Medicine , Henry Ford Hospital , Detroit , Michigan , USA.
  • 3 c Bassett Medical Center Department of Internal Medicine , Bassett Medical Center , Cooperstown, New York , USA.
Type
Published Article
Journal
Journal of investigative surgery : the official journal of the Academy of Surgical Research
Publication Date
Oct 12, 2017
Pages
1–3
Identifiers
DOI: 10.1080/08941939.2017.1380090
PMID: 29023177
Source
Medline
Keywords
License
Unknown

Abstract

Renal ischemia-reperfusion injury (IRI), an inevitable event during kidney transplantation procedure, can result in delayed graft function or even primary nonfunction. In addition to strategies to limit IRI such as advancements in organ allocation systems and preservation of organs, and reduction in cold and warm ischemia time, remote ischemic conditioning (RIC) has attracted much attention in recent years. With promising findings and data suggesting a potential benefit of RIC in animal kidney transplantation models, a few clinical trials have investigated the use of RIC in human kidney transplantation. Unfortunately, the findings from these investigations have been inconclusive due to a number of factors such as diverse time points of RIC, limited sample size, and complexity of kidney transplant patients. This brief commentary aims to discuss the effects of RIC on clinical outcomes and proinflammatory cytokines in patients undergoing kidney transplantation.

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