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Remodelling the malignant phenotype : impact of EMT

Authors
  • Said, Nur Akmarina B.M.
  • Williams, Elizabeth D.
Publication Date
Jan 01, 2009
Source
Queensland University of Technology ePrints Archive
Keywords
License
Unknown
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Abstract

Epithelial to mesenchymal transition (EMT) is a highly conserved programme of events essential for normal development. As it underpins cell plasticity, migration and invasion in a number of settings it is an attractive concept to apply to the malignant phenotype. Much is known about the molecular events regulating EMT in a number of model organisms, including Drosophila, sea urchin, zebrafish, xenopus and the chick. It is increasingly apparent that EMT is a highly conserved process, and that discoveries made in these systems provide excellent insights into the understanding of the role of EMT in human malignancies.

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