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Remodeling of outward K+ currents in pressure-overload heart failure.

Authors
  • Wang, Yanggan
  • Cheng, Jun
  • Chen, Guohua
  • Rob, Farhana
  • Naseem, R Haris
  • Nguyen, Lan
  • Johnstone, Janet L
  • Hill, Joseph A
Type
Published Article
Journal
Journal of Cardiovascular Electrophysiology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Aug 01, 2007
Volume
18
Issue
8
Pages
869–875
Identifiers
PMID: 17537202
Source
Medline
License
Unknown

Abstract

This is the first report of HF-related remodeling of outward K+ currents in murine LV. Similar to humans, disease-related remodeling occurs differentially across the murine ventricular wall, leading to loss of the native gradient of repolarization. Together with slowed recovery from inactivation, these alterations likely promote abnormal impulse conduction, a major proarrhythmic mechanism.

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