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A remarkably efficient synthesis of pure cis-stilbenoid hydrocarbons using trans-dibromoalkenes via palladium catalysis.

Authors
  • Rathore, Rajendra
  • Deselnicu, Mihaela I
  • Burns, Carrie L
Type
Published Article
Journal
Journal of the American Chemical Society
Publication Date
Dec 18, 2002
Volume
124
Issue
50
Pages
14832–14833
Identifiers
PMID: 12475309
Source
Medline
License
Unknown

Abstract

A remarkably versatile synthesis of cis-stilbenoid hydrocarbons containing highly functionalized phenyl groups is developed via an efficient palladium-catalyzed coupling of aryl Grignard reagents with trans-1,2-dibromoalkenes (generally obtained via bromination of the corresponding dialkylacetylenes) in tetrahydrofuran.

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