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A reliable method for establishing viral infection in the rabbit by intranasal inoculation.

Authors
  • Brown, G A1
  • Field, H J
  • 1 Department of Clinical Veterinary Medicine, University of Cambridge, U.K.
Type
Published Article
Journal
Journal of Virological Methods
Publisher
Elsevier
Publication Date
Mar 01, 1990
Volume
27
Issue
3
Pages
341–345
Identifiers
PMID: 2157733
Source
Medline
License
Unknown

Abstract

Bovine herpesvirus 1 (BHV-1) infection was established in the rabbit by a novel procedure which involved virus being injected through trephine openings on either side of the nose of anaesthetised animals. This method of intranasal inoculation produced more consistent reactions to BHV-1 inoculation, and both humoral and cell-mediated immune responses to the virus were of greater magnitude compared with those following per naris instillation of virus.

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