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Reliability of radiographic intervertebral disc height measurement for in vivo rat-tail model.

Authors
  • Lai, Alon
  • Chow, Daniel H K
  • Siu, W S
  • Holmes, Andrew D
  • Tang, F H
Type
Published Article
Journal
Medical Engineering & Physics
Publisher
Elsevier
Publication Date
Sep 01, 2007
Volume
29
Issue
7
Pages
814–819
Identifiers
PMID: 17023188
Source
Medline
License
Unknown

Abstract

Quantification of changes in intervertebral disc height is critical for studying intervertebral disc degeneration. Reliability of disc height measurement is therefore especially important for in vivo studies using animal models of disc degeneration. In this study, the effects of image intensity and percentage of disc width used for disc height measurement from radiographic images were evaluated in a rat-tail model. Radiographs were taken for 10 Sprague-Dawley rats using a standardized protocol. Average disc heights of the caudal 8-9 discs were determined using original and intensity adjusted images with different percentages of disc width. The average disc height was found to be significantly affected by both the image intensity and the percentage of disc width measured. A higher reliability was found in the measurement for image with adjusted intensity and using smaller disc width. Image intensity is suggested to be controlled and the disc width should be taken into account in quantifying the disc height.

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