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Relevance of tenascin-C and matrix metalloproteinases in vascular abnormalities in murine hypoplastic lungs.

Authors
  • Chinoy, Mala R
  • Miller, Shane A
Type
Published Article
Journal
Biology of the neonate
Publication Date
Jan 01, 2006
Volume
90
Issue
3
Pages
185–196
Identifiers
PMID: 16699260
Source
Medline
License
Unknown

Abstract

(1)TN-C is known to inhibit vascular SMC proliferation. But, decrease in TN-C in hypoplastic lungs may support the observed arterial SMC proliferation. (2) Our studies showed that in hypoplastic lungs the SMC apoptosis is not affected, thus suggesting that SMC proliferation and apoptosis may be two separate processes in pulmonary hypoplasia with coexistent diaphragmatic hernia. Together, our data showed an imbalance in the extracellular matrix proteins, which may contribute to the pulmonary vascular abnormalities.

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