Relevance of tenascin-C and matrix metalloproteinases in vascular abnormalities in murine hypoplastic lungs.
- Published Article
Biology of the neonate
- Publication Date
Jan 01, 2006
(1)TN-C is known to inhibit vascular SMC proliferation. But, decrease in TN-C in hypoplastic lungs may support the observed arterial SMC proliferation. (2) Our studies showed that in hypoplastic lungs the SMC apoptosis is not affected, thus suggesting that SMC proliferation and apoptosis may be two separate processes in pulmonary hypoplasia with coexistent diaphragmatic hernia. Together, our data showed an imbalance in the extracellular matrix proteins, which may contribute to the pulmonary vascular abnormalities.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/16699260