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Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells.

Authors
  • Costa, Natália R
  • Mendes, Nuno
  • Marcos, Nuno T
  • Reis, Celso A
  • Caffrey, Thomas
  • Hollingsworth, Michael A
  • Santos-Silva, Filipe
Type
Published Article
Journal
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Co
Publication Date
Mar 07, 2008
Volume
14
Issue
9
Pages
1411–1414
Identifiers
PMID: 18322957
Source
Medline
License
Unknown

Abstract

This work shows that MUC1 mucin variability conditions H pylori binding to gastric cells. The extent of bacterial adhesion depends on the size of the MUC1 VNTR domain. The adhesion is further dependent on bacterial pathogenicity and the gastric cell line. MUC1 mucin variability may contribute to determine H pylori colonization of the gastric mucosa.

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