Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells.
- Authors
- Type
- Published Article
- Journal
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Co
- Publication Date
- Mar 07, 2008
- Volume
- 14
- Issue
- 9
- Pages
- 1411–1414
- Identifiers
- PMID: 18322957
- Source
- Medline
- License
- Unknown
Abstract
This work shows that MUC1 mucin variability conditions H pylori binding to gastric cells. The extent of bacterial adhesion depends on the size of the MUC1 VNTR domain. The adhesion is further dependent on bacterial pathogenicity and the gastric cell line. MUC1 mucin variability may contribute to determine H pylori colonization of the gastric mucosa.
