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Relevance of endothelium-derived hyperpolarizing factor in the effects of hypertension on rat coronary relaxations.

Authors
  • Vázquez-Pérez, S
  • Navarro-Cid, J
  • de las Heras, N
  • Cediel, E
  • Sanz-Rosa, D
  • Ruilope, L M
  • Cachofeiro, V
  • Lahera, V
Type
Published Article
Journal
Journal of Hypertension
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Mar 01, 2001
Volume
19
Issue
3 Pt 2
Pages
539–545
Identifiers
PMID: 11327627
Source
Medline
License
Unknown

Abstract

NO and EDHF are the main endothelium-derived relaxing factors underlying acetylcholine and isoproterenol relaxations in rat coronary arteries, respectively. EDHF reduction, and not only NO reduction play a key role in the diminished coronary relaxations induced by acetylcholine and isoproterenol in SHR. An arachidonic acid derivative with contracting activity released by acetylcholine and isoproterenol in a differential manner, could oppose the relaxing actions of NO and EDHF.

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