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Release of soluble tumor necrosis factor receptor 1 from corneal epithelium by TNF-alpha-converting enzyme-dependent ectodomain shedding.

Authors
  • Sakimoto, Tohru
  • Yamada, Ai
  • Sawa, Mitsuru
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Oct 01, 2009
Volume
50
Issue
10
Pages
4618–4621
Identifiers
DOI: 10.1167/iovs.08-2669
PMID: 19407014
Source
Medline
License
Unknown

Abstract

TACE-dependent ectodomain shedding of sTNFR1 was recognized in corneal epithelium. In the inflamed ocular surface, TNFR1 was expressed in the corneal and conjunctival epithelia after alkali burn treatment. sTNFR1, released from the ocular surface, may play an anti-inflammatory role in the inflammatory condition.

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